This project focuses on development of nanosensor technology and software for detection of human, animal and plant pathogens that are highly significant biosecurity threats to public health and agriculture in Australia. The project is a collaboration between the CRC for National Plant Biosecurity (CRCNPB), Nanomics BioSystems, the Australian Biosecurity CRC for Emerging Infectious Disease (AB-CRC) and the Queensland Department of Primary Industries and Fisheries.

The technology comprises ceramic beads (OptoPlex^TM beads) on which biomolecular interactions (either DNA or protein-based) are detected, screened, analysed and reported. The technology will be optimised for generic detection devices and, potentially, hand-held devices for use in medical practices, ports and/or farms.

What is the biosecurity problem?

Biosecurity diagnostic protocols currently depend upon a complicated variety of tests based on a wide range of (often expensive) technological platforms. Each platform requires significant investment in single-use equipment and training. Despite this investment, results can be ambiguous and require multiple (and different) tests to produce a confirmed result for a single pest or pathogen. These factors can lead to delayed diagnoses and subsequent delays in responsiveness to biosecurity threats.

The main outputs of this project are to:

• develop a new diagnostic platform optimised for generic detection devices and, potentially, hand-held devices for use in medical practices, ports and/or farms.
• validate diagnostic assays for exotic pests and pathogens.

Who will be the end-users of this research?

The outputs of the project will be used by government/university and industry diagnostic labs and field-based (operational) biosecurity staff such as AQIS/NAQS and state government agencies.